Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC069
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-11-10 09:36
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250mg 1+1+1+1 old patient

Overall Assessment

non PD

Subject performance similar to non PD population

Clinical context

In the clinical reference population, 7 individuals with a value less than 0.53 were subsequently diagnosed with PD. That is, 16.67% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.53 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 22, 'TN': 17, 'TP': 20, 'FP': 13}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 26, 'TN': 22, 'TP': 16, 'FP': 8}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 27, 'TN': 22, 'TP': 15, 'FP': 8}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 13, 'TN': 9, 'TP': 29, 'FP': 21}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 7.864
timePerCircleCoV 0.265497
timePerCircleSlope -0.00308271
meanError 1.84302
tremorFreq 6.54297
tremorRelPower 59.9959
tremorGyroAmpMean 0.0428615
tremorGyroAmpSlope -0.00907018
tremorGyroAmpCoV 0.300509
tremorCoordAmpMean 0.0964671
tremorCoordAmpSlope -0.0106342
tremorCoordAmpCoV 0.289372
tremorAccAmpMean 0.0842678
tremorAccAmpSlope -0.0102696
tremorAccAmpCoV 0.293835
tremorPcRelVar 0.698057
tremorPcX -0.903205
tremorPcY -0.42921

Circle Segment 1

Duration 10.28 s, Accuracy Estimate 1.593 (lower is better)

Circle Segment 2

Duration 8.76 s, Accuracy Estimate 1.259 (lower is better)

Circle Segment 3

Duration 6.8 s, Accuracy Estimate 1.325 (lower is better)

Circle Segment 4

Duration 6.04 s, Accuracy Estimate 1.612 (lower is better)

Circle Segment 5

Duration 6.56 s, Accuracy Estimate 1.555 (lower is better)

Circle Segment 6

Duration 6.28 s, Accuracy Estimate 1.583 (lower is better)

Circle Segment 7

Duration 8.28 s, Accuracy Estimate 1.779 (lower is better)

Circle Segment 8

Duration 7.16 s, Accuracy Estimate 1.265 (lower is better)

Circle Segment 9

Duration 12.36 s, Accuracy Estimate 3.908 (lower is better)

Circle Segment 10

Duration 6.12 s, Accuracy Estimate 2.553 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 22.76
timePerSpiralCoV 0.08433
timePerSpiralSlope 0.00617777
meanError 2.0043
tremorFreq 6.64062
tremorRelPower 54.6386
tremorGyroAmpMean 0.0411022
tremorGyroAmpSlope 2.74021e-05
tremorGyroAmpCoV 0.289558
tremorCoordAmpMean 0.0822019
tremorCoordAmpSlope 0.000123962
tremorCoordAmpCoV 0.323262
tremorAccAmpMean 0.0685318
tremorAccAmpSlope 0.000206511
tremorAccAmpCoV 0.343406
tremorPcRelVar 0.80058
tremorPcX 0.979842
tremorPcY 0.199776

Spiral Segment 1

Duration 25.36 s, Accuracy Estimate 1.945 (lower is better)

Spiral Segment 2

Duration 22.96 s, Accuracy Estimate 1.78 (lower is better)

Spiral Segment 3

Duration 20.12 s, Accuracy Estimate 2.122 (lower is better)

Spiral Segment 4

Duration 21.2 s, Accuracy Estimate 2.066 (lower is better)

Spiral Segment 5

Duration 22.6 s, Accuracy Estimate 1.834 (lower is better)

Spiral Segment 6

Duration 21.68 s, Accuracy Estimate 2.13 (lower is better)

Spiral Segment 7

Duration 21.72 s, Accuracy Estimate 2.117 (lower is better)

Spiral Segment 8

Duration 22.36 s, Accuracy Estimate 2.011 (lower is better)

Spiral Segment 9

Duration 23.04 s, Accuracy Estimate 2.103 (lower is better)

Spiral Segment 10

Duration 26.56 s, Accuracy Estimate 1.936 (lower is better)

Elel

eDurationMean 0.731184
eDurationStd 0.191902
eDurationStdnorm 0.262453
eDurationMedian 0.66
eDurationQuartdelta 0.23
eDurationQuartdeltanorm 0.348485
eDurationKurt 3.80559
eDurationTrenddiff -0.23
eDurationTrendratio 0.724551
eWidthMean 4.01495
eWidthStd 1.02183
eWidthStdnorm 0.254507
eWidthMedian 3.744
eWidthQuartdelta 1.404
eWidthQuartdeltanorm 0.375
eWidthKurt 3.72433
eWidthTrenddiff -0.468
eWidthTrendratio 0.882353
eHeightMean 8.52253
eHeightStd 1.85543
eHeightStdnorm 0.217709
eHeightMedian 8.307
eHeightQuartdelta 1.872
eHeightQuartdeltanorm 0.225352
eHeightKurt 4.50525
eHeightTrenddiff -0.819
eHeightTrendratio 0.906667
eAspectMean 0.476118
eAspectStd 0.0888975
eAspectStdnorm 0.186713
eAspectMedian 0.460829
eAspectQuartdelta 0.114618
eAspectQuartdeltanorm 0.248721
eAspectKurt 3.51856
eAspectTrenddiff 0.0441495
eAspectTrendratio 1.10112
eSlantMean -0.099922
eSlantStd 0.144757
eSlantStdnorm -1.4487
eSlantMedian -0.106397
eSlantQuartdelta 0.151157
eSlantQuartdeltanorm -1.42068
eSlantKurt 2.98274
eSlantTrenddiff 0.083429
eRtopMean 0.544157
eRtopStd 0.143044
eRtopStdnorm 0.262872
eRtopMedian 0.538462
eRtopQuartdelta 0.145637
eRtopQuartdeltanorm 0.270469
eRtopKurt 4.27678
eRtopTrenddiff 0.06875
eRbotMean 0.799866
eRbotStd 0.331388
eRbotStdnorm 0.414304
eRbotMedian 0.740842
eRbotQuartdelta 0.327407
eRbotQuartdeltanorm 0.441939
eRbotKurt 9.57333
eRbotTrenddiff -0.0918114
eRrightMean 0.716216
eRrightStd 0.0923147
eRrightStdnorm 0.128892
eRrightMedian 0.722791
eRrightQuartdelta 0.13961
eRrightQuartdeltanorm 0.193153
eRrightKurt 2.63846
eRrightTrenddiff -0.00896287
eRleftMean 0.501722
eRleftStd 0.129353
eRleftStdnorm 0.257818
eRleftMedian 0.49359
eRleftQuartdelta 0.165752
eRleftQuartdeltanorm 0.33581
eRleftKurt 2.56276
eRleftTrenddiff -0.0615271
lDurationMean 1.34447
lDurationStd 0.290018
lDurationStdnorm 0.215711
lDurationMedian 1.335
lDurationQuartdelta 0.385
lDurationQuartdeltanorm 0.28839
lDurationKurt 3.31478
lDurationTrenddiff -0.365
lDurationTrendratio 0.752542
lWidthMean 6.25026
lWidthStd 1.12045
lWidthStdnorm 0.179265
lWidthMedian 6.2595
lWidthQuartdelta 1.287
lWidthQuartdeltanorm 0.205607
lWidthKurt 4.55157
lWidthTrenddiff -0.936
lWidthTrendratio 0.857143
lHeightMean 27.7567
lHeightStd 4.45061
lHeightStdnorm 0.160344
lHeightMedian 27.261
lHeightQuartdelta 7.254
lHeightQuartdeltanorm 0.266094
lHeightKurt 2.42058
lHeightTrenddiff -6.786
lHeightTrendratio 0.781955
lAspectMean 0.227407
lAspectStd 0.0360781
lAspectStdnorm 0.15865
lAspectMedian 0.226281
lAspectQuartdelta 0.0613241
lAspectQuartdeltanorm 0.271008
lAspectKurt 2.41792
lAspectTrenddiff 0.0289426
lAspectTrendratio 1.13346
lSlantMean -0.108228
lSlantStd 0.0828757
lSlantStdnorm -0.765754
lSlantMedian -0.109528
lSlantQuartdelta 0.114793
lSlantQuartdeltanorm -1.04807
lSlantKurt 2.47274
lSlantTrenddiff 0.0119134
lRtopMean 0.692047
lRtopStd 0.0907599
lRtopStdnorm 0.131147
lRtopMedian 0.704989
lRtopQuartdelta 0.125
lRtopQuartdeltanorm 0.177308
lRtopKurt 2.87454
lRtopTrenddiff 0.0520208
lRbotMean 1.21194
lRbotStd 0.375981
lRbotStdnorm 0.310229
lRbotMedian 1.17468
lRbotQuartdelta 0.514605
lRbotQuartdeltanorm 0.438083
lRbotKurt 3.19896
lRbotTrenddiff -0.0577915
lRrightMean 0.837077
lRrightStd 0.0855575
lRrightStdnorm 0.10221
lRrightMedian 0.850715
lRrightQuartdelta 0.0618772
lRrightQuartdeltanorm 0.0727355
lRrightKurt 6.77692
lRrightTrenddiff 0.00566923
lRleftMean 0.523351
lRleftStd 0.151902
lRleftStdnorm 0.29025
lRleftMedian 0.517047
lRleftQuartdelta 0.255326
lRleftQuartdeltanorm 0.493817
lRleftKurt 2.01807
lRleftTrenddiff 0.0400312

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

FITTS Short Modified

meanTouchScore 0.996931
sumTouchScores 16.9478
meanMovementTime 1.17125
numTouches 17
undershootPercentage 0
overshootPercentage 0

FITTS Long Modified

meanTouchScore 0.922999
sumTouchScores 12.922
meanMovementTime 1.43
numTouches 14
undershootPercentage 7.14286
overshootPercentage 0

ZigZag

numZigzags 5
timePerZigzagMean 33.864
timePerZigzagCoV 0.035175
timePerZigzagSlope -0.016773
meanError 1.80453
tremorFreq 6.83594
tremorRelPower 32.5025
tremorGyroAmpMean 0.051439
tremorGyroAmpSlope 0.000431024
tremorGyroAmpCoV 0.333416
tremorCoordAmpMean 0.0891595
tremorCoordAmpSlope 0.00124191
tremorCoordAmpCoV 0.386729
tremorAccAmpMean 0.0830756
tremorAccAmpSlope 0.00157043
tremorAccAmpCoV 0.410886
tremorPcRelVar 0.568935
tremorPcX -0.740253
tremorPcY -0.672328

ZigZag Segment 1

Duration 35.96 s, Accuracy Estimate 1.894 (lower is better)

ZigZag Segment 2

Duration 33.68 s, Accuracy Estimate 1.749 (lower is better)

ZigZag Segment 3

Duration 33.12 s, Accuracy Estimate 1.682 (lower is better)

ZigZag Segment 4

Duration 33.2 s, Accuracy Estimate 1.748 (lower is better)

ZigZag Segment 5

Duration 33.36 s, Accuracy Estimate 1.949 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 28.2
timePerZigzagCoV 0.180175
timePerZigzagSlope -0.0683688
zigzagHeightMean 75.2716
zigzagHeightCoV 0.0853086
zigzagHeightSlope 0.0448054
meanError 0.0409735
tremorFreq 6.54297
tremorRelPower 57.3605
tremorGyroAmpMean 0.0644534
tremorGyroAmpSlope -0.00104616
tremorGyroAmpCoV 0.294723
tremorCoordAmpMean 0.0944038
tremorCoordAmpSlope 0.000539333
tremorCoordAmpCoV 0.283643
tremorAccAmpMean 0.0838575
tremorAccAmpSlope 0.000472415
tremorAccAmpCoV 0.296223
tremorPcRelVar 0.798828
tremorPcX -0.40399
tremorPcY -0.914763

ZigZag Offset Segment 1

Duration 27.4 s, Accuracy Estimate 0.022 (lower is better)

ZigZag Offset Segment 2

Duration 36.56 s, Accuracy Estimate 0.056 (lower is better)

ZigZag Offset Segment 3

Duration 27.68 s, Accuracy Estimate 0.028 (lower is better)

ZigZag Offset Segment 4

Duration 26.64 s, Accuracy Estimate 0.024 (lower is better)

ZigZag Offset Segment 5

Duration 22.72 s, Accuracy Estimate 0.074 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.81}
RanFor {‘RanFor_class’: ‘NOT PD’, ‘RanFor_score’: 0.53}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.9184210556313368}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9375883246548791}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.567105933624098}